This workshop covers the use of the microscope in both early pharmaceutical development when the form is chosen and in later stages of development where the form is monitored for stability.
Details
Please contact us if you would like to take this workshop.
Targeted Participants
This course is designed for the skilled analyst who is familiar with the basic pharmaceutical microscopy instruments. The emphasis of the workshop is on the practical application of microscopy in the analysis of polymorphism.
The EMS Microscopy Academy
Located in Hatfield, Pennsylvania, the Academy provides electron microscopy classes, workshops and training sessions for all fields of microscopy, including materials science and biological science.
Format
Lecture, demonstration and hands-on practice, as well as round table table tips and tricks discussion. Participants are encouraged to bring their own samples, if possible.
Main Curriculum
The material in this workshop is broadly separated by development phase into form discovery and form understanding. Form discovery usually occurs before first time in human (FTIH) into Phase 1. Form understanding generally occurs in Phase 1 and Phase 2, although some work extends into Phase 3.
This workshop emphasizes the role of microscopy in each aspect of form understanding. Although we will discuss solid-state theory and fundamentals, the workshop relies heavily on case studies, demonstrations, and instrument usage.
Instruments Available
- Polarizing Light Microscope
- Hitachi S3500 SEM
- COXEM SEM EM-30N
- Image Analysis Software
- Linkam Thermal Microscope
- Bruker Esprit (SDD)
- IR and Raman Microscopes
Enrollment Note
Registration will be limited to a maximum of 15 participants.
EMS will provide samples to those who prefer not to bring their own.
Pharmaceutical Microscopy: Polymorphism
The choice of the optimum solid-state form is critical for successful pharmaceutical development. Broadly defined, form includes polymorphs, hydrates, solvates, salts, co-crystals etc. Microscopy is well- suited to the study of solid-state form.
This workshop covers the use of the microscope in both early pharmaceutical development when the form is chosen and in later stages of development where the form is monitored for stability.
It covers the material in Chapter 8 Pharmaceutical Microscopy (Springer, 2011) along with selections from other chapters. The course emphasizes how microscopy is used in conjunction with other analytical techniques for form selection and analysis.